Ing tanggal 9 November 2021, varian sakaviruscorona anyarB.1.1.529 dideteksi kanggo pisanan saka sampel kasus Afrika Kidul.Kurang saka 2 minggu, galur mutan dadi galur mutan sing dominan ing kasus infeksi mahkota anyar ing Afrika Kidul, lan wutah kanthi cepet wis narik perhatian global.Ing tanggal 26 November, galur mutan iki wis ditetepake dening WHO minangka "varian keprihatinan" (VOC) kaping lima, dijenengi minangka mutan Omicron (Omicron).Saiki, galur varian Omicrom wis nyebar kanthi cepet menyang 19 negara utawa wilayah ing saindenging jagad, lan bisa nyebabake tantangan anyar kanggo nyegah lan ngontrol epidemi global.
WHO uga nyatakake yen Omicron duwe mutasi akeh, sawetara sing kuwatir.WHO uga nyatakake yen galur mutan "Omicron" dideteksi luwih cepet tinimbang galur mutan liyane sing nyebabake lonjakan infeksi ing jaman kepungkur, nuduhake yen galur mutan paling anyar iki bisa uga duwe keuntungan pertumbuhan.Nyegah kanthi ketat panyebaran galur mutan koronavirus anyar Omicron wis dadi target anyar kanggo nyegah epidemi global
Peta distribusi mutasi Omicron(1）lan Delta(2）, Universitas Stanford Coronavirus lan Database Resistance Narkoba
Saliyane nduweni mutasi luwih akeh ing protein spike, galur mutan Omicron uga nduweni pirang-pirang situs mutasi ing protein N.Amarga target utama reagen deteksi antigen koronavirus anyar yaiku protein N, mutasi protein N bisa mengaruhi antigen koronavirus anyar.Akurasi kit tes duwe pengaruh.
| Tabel 1. Perbandingan evolusi protein N saka macem-macem mutan
| |
| Jenis virus
| Evolusi protein N |
| Alfa(B.1.1.7) | R203K；G204R;(>50%) S194L(5-50%) D3H;D63G;T205I;M234I(1-5%) |
| Beta (B.1.351) | T205I (>50%) P13S;T3621(5-50%) Q9H;Q28R;A35T;E38V;Q418H (1-5%) |
| Gamma (p.1) | P80R;S202C;R203K;G204R (>50%) A211S;D402Y;S4131 (1-5%) |
| Delta(B.1.617.2) | D63G;R203M;G215C;D377Y (>50%) Q9L(>5-50%) G18V;R385K (1-5%)
|
| Omicron(B.1.1.529) | P13L;R203K;G204R E31/R32/S33 Del |
Dibandhingake karo protein Alpha-N, protein Omicron-N nduweni bedane 10 posisi asam amino.Kanggo nyelidiki kinerja deteksi protein Omicron-N dening bahan mentah antibodi covid-19 saka gen Keygen, kita nyiapake protein Omicron-N rekombinan ing pisanan, Lan nindakake verifikasi kolaborasi dening Keygen Gene lan sawetara pelanggan.Asil nuduhake yen open view gen materi antibodi mahkota anyar duwe asil deteksi padha kanggo protein Omicron-N rekombinan, protein Alpha-N lan protein Delta-N.Materi antibodi mahkota anyar gen tampilan mbukak bisa njamin akurasi kit antigen virus mahkota anyar kanggo deteksi varian Omicron..
| Tabel 2 Asil deteksi protein N rekombinan Omicron dening antibodi neokorona | ||||||
| Antibodi dipasangake | Alpha-Nprotein | Omicron-Nprotein | ||||
| 4.0ng/ml | 2.0ng/ml | 1.0ng/ml | 4.0ng/ml | 2.0ng/ml | 1.0ng/ml | |
| Rencana 1 | G5 | G4 | G2 | G5 | G4 | G2 |
| Rencana 2 | G5 | G4 | G2 | G5 | G4 | G2 |
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Wektu kirim: Dec-14-2021
